On TV, San Giacomo has starred in the ABC movie "For Their Own Good" (1993) and in the highly acclaimed miniseries "Steven King's 'The Stand'" (ABC, 1994). She earned a CableACE Award nomination for her performance in Showtime's "The Right to Remain Silent" (1996), playing an HIV-positive high school teacher arrested for slicing open a vein at a school board meeting to protest her dismissal. Although she had made guest appearances on such series as "Crime Story", "Miami Vice" and "The Equalizer", San Giacomo landed her first regular role as Maya Gallo, a journalist working for her father (George Segal) at a trendy magazine, in "Just Shoot Me" (NBC, 1997- ). She was once all set to play the lead in a film on the life of Mexican artist-icon Frida Kahlo, but the project fizzled over protests about her non-Mexican heritage.