Born on Aug. 30, 1963 in Lowell, MA, Chiklis was raised to be an entertainer almost from the start. Reared in a musical household, he was accustomed to breaking into song and entertaining his large Greek family by the time he was five years old. Chiklis also developed an impressive array of celebrity impressions – some 100 all told, including Richard Nixon, Marlon Brando and James Cagney. In junior high, a teacher encouraged him to audition for summer stock for the Town & Country Playhouse in Salem, NH. He moved on to the Merrimack Repertory Theatre in hometown Lowell where Chiklis earned his Equity card from the stage union at just age 13, acting in a production of “Romeo and Juliet.” After graduating from Andover High School – where he played baseball, hockey and was the captain of the football team – Chiklis eschewed athletic scholarships in order to attend Boston University’s prestigious School of Fine Arts drama program.

In 1985, Chiklis graduated from Boston University and moved to New York City to pursue his acting career. For the first few years, he waited tables and tended bar, while going on auditions and acting in regional theater and in off-Broadway productions. Because of his distinctive look – he played the part of a 65-year-old man in college in “You Can’t Take It with You,” using grease paint on his then-full head of hair that was not removed properly, killing the follicles – Chiklis was generally cast in older roles. He landed his first big break after 12 auditions to play the role of tragic comic John Belushi in "Wired" (1989), the feature adaptation of Bob Woodward’s hard-hitting 1984 biography of the late comedian, which dealt extensively with Belushi's drug abuse. Controversy and litigation, however, kept the film from opening on schedule – as many industry figures and friends named in the book did not like the tone of the film as it pertained to their involvement or the memory of their friend. Particularly vocal against anyone to do with the film was Dan Aykroyd, Belushi’s best friend and onscreen comedy partner, and Jim Belushi, John’s younger brother. When it did, the movie was shunned by Hollywood and overlooked by the public.

In 1989, Chiklis made his TV movie debut as an evangelist hoping to benefit from a child preacher's trust fund in "Blues for Buder," an installment of Burt Reynolds’ rotating movie mystery vehicle, "B.L. Stryker” (ABC, 1989-1990). He also appeared as a sexist comedian in "Murphy Brown" (CBS, 1988-1998); a cop-turned-thief on “Miami Vice” (NBC, 1984-89); and a drunk on “Seinfeld” (NBC, 1988-1998). In 1991, Chiklis was cast in his first regular series as the titular character on "The Commish” – about an unorthodox police commissioner in upstate New York dealing with the job while, at the same time, remaining a devoted husband and father. The show proved to be a middling success in its niche on Saturday nights. After its regular run ended in 1995, Chiklis came back for several two-hour movies during the 1995-96 season. He made a few sporadic film appearances, co-starring in the little-seen "The Rain Killer" (1990) and playing a television director in Oliver Stone's "Nixon" (1995). He returned to TV as the star of the NBC midseason replacement family sitcom "Daddio" in 2000, which showed initial ratings potential but faded quickly. The actor then equated himself well in the iconic role of Jerome 'Curly' Howard in the ABC biopic "The Three Stooges" (2000).

Chiklis would go two years before his next major gig. Chaffing at his lightweight image, he bucked his previous typecast image by shaving his head, getting himself into shape and adopting a more tenacious demeanor to play Vic Mackey on "The Shield” – an original drama created by Shawn Ryan for the then fledgling FX network. Chiklis was compelled by his morally compromised antihero, whose over-the-line tactics often served justice better than the law, but who also killed a fellow officer to protect his undercover Strike Team after they had enriched themselves with the ill-gotten gains from criminals they had taken down. As the show grew in popularity, Chiklis famously refused to comment on his own view of Mackey's morality, keeping the audience guessing as to any possible chance of redemption. Meanwhile, both actor and character fused perfectly – Chiklis' intense portrayal resulted in a slew of critical praise, nominations and awards – including a surprise Emmy for Outstanding Lead Actor in a Drama Series in 2002, followed shortly by a Golden Globe for Best Performance by an Actor in a Television Series Drama in early 2003.

Because of his success on "The Shield," Chiklis was tapped by Marvel Productions and 20th Century Fox to star as the Marvel Comics superhero, The Thing, in the big-screen, big-budget adaptation of the classic Stan Lee-Jack Kirby comic book "The Fantastic Four.” Playing Ben Grimm, a shuttle pilot whose exposure to cosmic rays turns him into a hulking, super-strong, blue-eyed creature with a rocky hide, Chiklis took on the role wholeheartedly, playing the character in a full body suit and make-up, as opposed to simply voicing a CGI creation – though he did admit to requiring therapy to deal with the claustrophia-inducing costume. The actor's efforts were undermined, however, by the unconvincing Thing suit as well as the film's wildly uneven script and direction. Despite the therapy, uncomfortable suit and mediocre film, Chiklis revived The Thing in “Fantastic Four: Rise of the Silver Surfer” (2007) which end result was the same as its predecessor – big box office totals and a critical drubbing.