The Perfect Storm star will open in the play at the Goodman Theatre in Chicago, Illinois in September (12).
She’ll play a fading movie star, opposite young Broadway actor Finn Wittrock, who will portray her toyboy love interest.
Nicole Kidman and James Franco were once attached to the project, when it was slated to become a straight-to-Broadway production.
The 1950s play originally featured Geraldine Page and Paul Newman, who reprised their roles in the hit 1962 movie. Irene Worth won a Tony Award for her performance in a 1970s revival.