The film, starring Leonardo DiCaprio, was awarded trophies including Best Science Fiction Film, while Nolan was handed titles for Best Director and Best Writing at the annual science fiction, fantasy and horror ceremony.
Other winners on the night included Jeff Bridges, who won Best Actor for his role in Tron: Legacy, while Natalie Portman picked up the female equivalent for Black Swan. Meanwhile, the Best Supporting Actor and Actress gongs went to Andrew Garfield (Never Let Me Go) and Mila Kunis (Black Swan), respectively.
Teenage actress Chloe Moretz was also honoured for Best Performance by a Younger Actor (Let Me In) at the ceremony in Burbank, California, while Alice In Wonderland was named Best Fantasy Film.
In the TV categories, Fringe was hailed Best Network series, seeing off competition from the likes of Lost and Smallville, while the show’s Anna Torv was named Best Actress in Television.
Stephen Moyer won Best Actor in Television for True Blood.