Fassbender pulled in a haul of nominations for his portrayal of a sex addict in the gritty 2011 drama, including nods for Best Actor at the Golden Globes and the British Academy of Film and Television Arts awards (BAFTA).
His performance is now in contention for a top acting prize at the 25th EFAs, where he faces competition from Mads Mikkelsen (Jagten), Gary Oldman (Tinker Tailor Soldier Spy), Jean-Louis Trintignant (Amour), and The Intouchables co-stars Francois Cluzet and Omar Sy.
Shame is also up for another four trophies, including European Film, European Director for Steve McQueen, European Cinematographer Award and European Editor.
Alongside Shame, the other nominees for European Film 2012 are Amour, Barbara, Jagten, Cesare Deve Morire and The Intouchables.
Kate Winslet is included in the Best Actress category for her turn in Roman Polanski’s Carnage, and is up against Margarethe Tiesel (Paradies: Liebe), Emmanuelle Riva (Amour), Nina Hoss (Barbara), and Emilie Dequenne (A Perdre La Raison).
Dame Helen Mirren will be presented with a lifetime achievement award at the ceremony, which will take place in Malta on 1 December (12).