A young man is looking for the woman he loves, though he wouldn't know her if he saw her in this teen-oriented comedy. Matthew (Jonathan Tucker) is a college freshman who has not been having much luck with the ladies since he started school. One night, Matthew is taking an elevator downstairs at his dorm when someone dashes in just as the door is closing. Moments later, there's a power outage, and Matthew and his fellow passenger are stuck. He soon discovers that he's stranded on the elevator with a woman, and they strike up a conversation; one thing leads to another, and they end up making love. However, Matthew never gets her name or a good look at her face in the darkness, and the next morning, he awakes to discover the power is back on, and the young woman is gone. Matthew is desperate to find her, certain that she is the love of his life, but all he knows for sure is that she lives in a nearby all-girls dorm -- and that she left behind a pair of panties. Posing as a maintenance man, Matthew sets out to visit every girl in the dorm, hoping to find the girl who matches up to the lingerie. Among the many women Matthew runs across in search of his dream girl in 100 Girls are Larisa Oleynik, Jaime Pressly, Katherine Heigl, Marissa Ribisi, and Emmanuelle Chriqui.