The three most glamorous and butt-kicking private detectives in the business are back and ready to take on bad guys in this sequel to the 2000 blockbuster screen adaptation of the once-popular television series. Dylan (Drew Barrymore), Natalie (Cameron Diaz), and Alex (Lucy Liu) are once again summoned to the office of their boss Charlie (voice of John Forsythe), where they're introduced to his new right-hand man Jimmy Bosley (Bernie Mac) and given their latest assignment. It seems a pair of rings have gone missing and need to be recovered, but this was no ordinary jewel heist -- the rings have been coded with special information that can be used to access a list of every person in the FBI's Witness Protection Program, and when a handful of protected informants are murdered, the Angels are brought in to help crack the case. As the women search for the culprits, they encounter Madison Lee (Demi Moore), one of Charlie's former agents who decided that the wrong side of the law pays better, and Seamus (Justin Theroux), who once dated Dylan and wants revenge for her decision to turn him over to the police. Luke Wilson and Matt LeBlanc return as (respectively) Natalie and Alex's love interests, as does Crispin Glover as the Thin Man; John Cleese, Robert Forster, and Eric Bogosian also appear in supporting roles.