Mark Decena makes his directorial debut with the romantic comedy Dopamine. In San Francisco during the economic heyday of computer technology, Rand (John Livingston) works as a software designer. He and his co-workers, Winston (Bruno Campos) and Johnson (Reuben Grundy), have created a toy called Koy Koy, an A.I. cyber-pet that can respond to its owner's voice. Rand's love life hasn't been very productive, especially because his father (William Windom) has been repeatedly telling him that love is just a series of chemical reactions ever since his mother was diagnosed with Alzheimer's disease. One day, Rand goes out to the bar after work and meets preschool teacher Sarah (Sabrina Lloyd), whom he feels strongly attracted to. When his company test markets his cyber-pet to little kids, Rand meets Sarah again and they are instantly connected. Despite their differing opinions on the chemical nature of love, Rand and Sarah begin a romance that puts their theories to the test. The film also stars Kathleen Antonia and Nicole Wilder. Shot on digital video, Dopamine premiered at the 2003 Sundance Film Festival.
~ Andrea LeVasseur, All Movie Guide