A fierce woman warrior joins a wandering demon hunter on his quest to recover the missing body parts and regain his natural form in director Akihiko Shiota's adaptation of Osamu Tezuka's popular manga of the same name. Years ago, malevolent ruler Daigo Kagemitsu promised to deliver his unborn son to the forty-eight devils of the underworld in exchange for the power to conquer his country. When his son was born with forty-eight body parts missing, Daigo knew he had gotten his wish and cast the infant child into the river. Rescued from certain death and given the name Hyakkimaru (Satoshi Tsumabuki) by a poor herb doctor, the boy was outfitted with a glass eye, fitted with artificial limbs, and raised amidst the confusion of war. Now, every time Hyakkimaru slays a demon, he regains another one of his missing body parts. One day, as Hyakkimaru does battle with a particularly fierce spider demon, a scrappy female thief named Dororo (Kou Shibasaki) takes notice and comes to his aid. Fascinated by the strange sword affixed to Hyakkimaru's artificial arm and awestruck by the fact that he somehow managed to grow a new leg after defeating the giant spider, Dororo agrees to follow Hyakkimaru on his journey after learning of his story from an ageing minstrel. But while Dororo is a fearless ally indeed, she has a troublesome habit of getting into mischief at the most awkward times. Later, as Hyakkimaru prepares to face off against his powerful father - he leaves his new friend behind in order to face his fate alone.