Intrigued by the recent trend of scientists, journalists, philosophers, and teachers who have been ostracized and discredited for daring to suggest that humankind may be the product of intelligent design rather than a random fluke in the cosmic scheme of things, Ben Stein sets out on a journey to investigate the supposed persecution of the many by the select few. Stein asserts that in recent years, anyone who dares to question the idea that adaptation is responsible for the development of Earth's organisms is held to ridicule, and over the course of the film, he travels the globe to speak with the supporters of both theories, pondering the reasons why believing in a higher power has seemingly become a massive taboo in the eyes of educators and the media.