An international assassin known only as Agent 47 (Timothy Olyphant) carries out high-profile hits for a mysterious organization known only as "The Agency" in this adaptation of the popular Eidos Interactive video-game series. Agent 47 is an elite, genetically engineered assassin who takes great pride in his work. His lethal grace, steady shot, and unparalleled precision have all served to make him one of the most sought-after assassins in the world. But when the killer without a conscience is faced with an unanticipated series of developments, his entire perception of reality begins to shift. On assignment to take out Russian head of state Belicoff (Ulrich Thomsen), Agent 47 is caught off guard by the appearance of presidential look-alikes. When the high-profile hit captures the attention of such powerful intelligence organizations as the CIA and Interpol, agent Mike Whittier (Dougray Scott) is dispatched to rein Agent 47 in. Meanwhile, a mysterious Russian prostitute named Nika (Olga Kurylenko) has walked into Agent 47's life, causing the methodical killer to become overwhelmed by emotions that were previously foreign to him.