Two dogs and a cat, separated from their human family, must find their way home and face the dangers of a big city for the first time in this adventure story for the whole family. Bob Seaver (Robert Hays) and his wife Laura (Kim Greist), who live in Northern California, are taking their kids on a camping vacation in Canada, and they're bringing along their pets -- spunky bulldog Chance (voice of Michael J. Fox), self-centered Himalayan cat Sassy (voice of Sally Field), and wise old Golden Retriever Shadow (voice of Ralph Waite). However, Chance doesn't like being cooped up in his travelling cage at the airport, and when he escapes, Sassy and Shadow follow him to the nearest city, San Francisco. After a scary night on their own, the trio are befriended by a gang of stray dogs and cats who have learned to live on their own after running away from their cruel masters. However, Chance, Sassy, and Shadow soon realize that life on the streets is not for them, and they set out to find the Seaver house they call home. Sports fans take note: Bob Uecker, Tommy Lasorda, and Al Michaels appear as themselves and also provide the voices of their pets. The voice of Shadow was performed by Don Ameche in the preceding film Homeward Bound; it proved to be Ameche's last film released before his death in late 1993 (his final film, Corrina, Corrina, didn't reach theaters until several months after his passing), leading the producers of this sequel to cast Ralph Waite in the role.