Director Michael Apted's Inspirations (1997), which explored the nature of creative talent, laid the groundwork for this film in which he investigates scientific brilliance. Apted interviews seven noted figures from divergent fields, including elderly pharmaceutical chemist Gertrude Elion, bestselling author and theoretical physicist Michio Kaku, and MIT linguist Steven Pinker. With wit and radiate intelligence, they discuss their obsessions, observations on life, and the mental processes that brought about their own noted discoveries. Me & Isaac Newton was screened at the 1999 Toronto Film Festival.
~ Jonathan Crow, All Movie Guide