Chevy Chase stars, though not always visibly, as Nick Halloway, a low-level businessman with an acerbic approach to life and work, whose humdrum existence utterly bores him. Nick gets an unexpected jolt of excitement when, nursing a hangover, he's the only one not to evacuate an office building that becomes a disaster area after a mishap involving nuclear testing equipment. An unexpected by-product of the accident is that it turns the molecules of the building, as well as Nick and the clothes he's wearing, transparent. When a team of shady government agents, led by David Jenkins (Sam Neill), notices that a human has been turned invisible, they try to take him into custody, planning to use him as the most dangerous secret intelligence agent the world has ever known. Distrusting their motives, the frantic and confused Nick escapes, and quickly begins learning new information about his unusual condition, such pragmatic details as trying to sleep when he can see through his eyelids and any unprocessed food he eats will give him away. Soon, however, he discovers that the scientist in charge of the experiments (Jim Norton) has no idea how to return him to normal, and begins plotting how best to live a semblance of a normal life while steering clear of his pursuers. Nick involves a beautiful woman he met the night before the accident (Daryl Hannah) in his dilemma, and soon she too becomes a target. Memoirs of an Invisible Man was adapted from a book by H.F. Saint.
~ Derek Armstrong, All Movie Guide