An officer of the law becomes a wanted man while trailing a killer in this crime drama. Jack Murphy (Charles Bronson) is a police detective who helped to put Joan Freeman (Carrie Snodgress), a psychotic murderer, behind bars ten years ago. However, Joan is now back on the street and determined to get revenge on Jack. She kills Jack's ex-wife and her new husband, and she cleverly frames the detective for the crime. Jack is arrested and taken into custody handcuffed to Arabella McGee (Kathleen Wilhoite), a rough-and-ready young hoodlum picked up for theft. Jack is able to escape, and has to track down Joan in order to clear his name with Arabella as his unwitting accomplice. Murphy's Law also features Lawrence Tierney and Richard Romanus.