Peter Farrelly and Bobby Farrelly, the impish impresarios of gross-out comedy, take their body function-inspired humor to new extremes in this mixture of live action and animation. Bill Murray stars as Frank, a zoo worker suffering from the effects of an unknown malady he contracted after eating an egg contaminated with simian saliva. Unknown to Frank, the inside of his body is actually a city (the City of Frank) teeming with cellular life, where the mysterious illness he's fighting is an invading enemy that must be defeated at all costs. It's up to Osmosis Jones (voice of Chris Rock), a white blood cell cop, and Drix (voice of David Hyde Pierce), a rookie over-the-counter medication, to hunt down and stop a lethal virus (Laurence Fishburne) who's got an inferiority complex. Along the way, the partners visit Frank's runny nostrils (Booger Dam) and a bar called, appropriately enough, the Zit. Osmosis Jones costars Molly Shannon and Chris Elliott, and features the vocal talents of William Shatner, producer Joel Silver, and singer Brandy Norwood.
~ Karl Williams, All Movie Guide