Bruce McDonald, critically acclaimed director of The Tracey Fragments, teams with A Clockwork Orange author Anthony Burgess to adapt Burgess' own novel about a small town in the grip of a mysterious frenzy. It may be Valentine's Day, but for caustic radio personality Grant Mazzy (Steohen McHattie) that's just another reason to be miserable. Mazzy used to be a certified radio superstar, but working in Pontypool is a far shot from working in the big city. But today, as Mazzy prepares for his regular routine of reading the weather, updating school closings, and pleading his case for a little on-air controversy to producer Sydnie Bryer (Lisa Houle), the arrival of an unexpected visitor signals the beginning of a disturbing phenomena in the small town of Pontypool. Heading to work, Mazzy is nearly run over by a distraught woman who seems to have lost her grip on reality. Later, reports of a shootout between provincial police and a group of local ice fishers is made even more bizarre by the revelation that they were all screaming gibberish, running around nude, missing body parts, and reportedly drunk. By the time a riot breaks Dr. Mendes (Hrant Alianak)' office it's obvious to Mazzy that the residents of Pontypool are suffering from a strange form of contagious dementia, but what has caused this bizarre outbreak and, more importantly, how can it be stopped?