Based on the autobiography by George and Anna Rose, Room for One More is a warm-hearted vehicle for husband-and-wife actors Cary Grant and Betsy Drake. Though she already has three children of her own, New Jersey housewife Anna Rose (Drake) adopts several kids born into less fortunate circumstances. Both Anna and her husband "Poppy" (Grant) must contend with the emotional baggage brought to their home by these "unwanted" kids, and both bear up quite well. The film's dramatic core concerns the Roses' efforts to reach a desperately unhappy 13-year-old girl (Iris Mann) and a physically handicapped boy with a penchant for getting into serious trouble (Clifford Tatum Jr). Despite occasional moments of anguish and pathos, Room for One More for the most part opts for a light-hearted approach to its subject matter. In 1962, a TV sitcom version of Room for One More, starring Andrew Duggan and Peggy McCay, debuted as a mid-season replacement over the ABC network; at that time, the original film was re-titled The Easy Way.
~ Hal Erickson, All Movie Guide