The ever-naïve Cindy Campbell, seeking a career in home healthcare, finds work with a creepy old lady in an even creepier old house haunted by a ghostly presence. Throw in a good-looking guy next door and the threat of aliens intent on global domination and Cindy's instantly up to the top of her extremely blond head in danger. Our fearless heroine catapults into action once again struggling to decipher ominous messages from the beyond, looking for love in some very weird places and trying to save the world from mass destruction. As she struggles to discover life-saving answers, Cindy encounters horrific plane crashes, bodacious blind girls, village idiots, disheveled rappers, kinky contraptions, psycho survivalists, alien sphincters and even Oprah!