Dr. Calvin Crosse (Philip M. Thomas) is a doctor just out of medical school, and he has moved to a small New England town to set up a medical practice. He's black, however, and the townspeople are pretty bigoted. Things don't look too good. The sheriff (Peter H. Clue) of the town started a whole wave of trouble when he infected his wife, long ago, with syphilis. The disease spread to their unborn daughter. Now grown, and very contagious, the daughter (Josie Johnson) has been having group sex with the town's young people in order to pay the old man back for his crimes. The doctor has to treat her victims and track down the disease's source. Vietnam Veteran Bill Waco (Harlan Cary Poe) assists him in this.