Despite its title, Tanganyika was largely filmed in the wilds of Universal City. Set in 1900, the film stars Van Heflin as safari guide John Gale, hired to launch a manhunt for the murderous Abel McCracken (Jeff Morrow). Deep in the territory controlled by the Nukumbi tribe, McCracken has been using the natives for his own reign of terror agains the British settlers of Tanganyika. Along for the chase are McCracken's honest brother Dan (Howard Duff), schoolmarm Peggy (Ruth Roman), and two precocious kids (Noreen Corcoran, Gregory Marshall). Gale's motives have nothing to do with justice, or even the charms of Peggy; he hopes to stake a claim on a piece of valuable African real estate. A climactic man-to-man battle between Gale and McCracken brings the proceedings to a rousing conclusion.