This bizarre entry into the disaster film genre concerns a group of hapless passengers aboard a transcontinental luxury train who are infected with a viral plague by a group of terrorists. Burt Lancaster plays military man Mackenzie, who wants to send the train across a rickety bridge so all the passengers will die, with Mackenzie reasoning the tragedy will give the terrorist movement a bad name. Among the passengers on the train trying to build up antibodies are Jennifer Rispoli Chamberlain (Sophia Loren); Nicole (Ava Gardner), who is embroiled in an affair with a younger man named Robby Navarro (Martin Sheen); and Dr. Jonathan Chamberlain (Richard Harris), a physician who wants to save the passengers but ends up duking it out with the terrorists.