When a Cape Kennedy space mission is interrupted by terrorists, Senator Stockwell (John Carter) turns to a massive computer for an analyzed report of which secret agents to trust with the case. The electronic brain suggests the Doll Squad, a crack team of highly trained female spies who are as beautiful as they are deadly. Their leader, Sabrina Kincaid (Francine York), is sent to round up the girls, but there's a mole in the Senator's organization, and the first two agents she contacts are murdered. Intelligence reports reveal that the head of the terrorist operation is Eamon O'Reilly (Michael Ansara), an ex-government agent and Sabrina's former lover. O'Reilly sends a carrier pigeon to the Senator with instructions to send back secret nuclear weapon plans, and threatens national disaster if he refuses. The mole is rooted out and the location of O'Reilly's secret island hideout is discovered, so Sabrina rounds up the rest of the Doll Squad and the ladies charter a boat. Once on shore, the girls are kidnapped, and O'Reilly explains his nefarious plans to Sabrina: He is going to spread bubonic plague across the civilized world and rule what is left with supreme power. But if she so desires, he'll inoculate her with the antidote and she will reign by his side as Queen. The Doll Squad fights back, using an arsenal of secret weapons, plastic explosives, and their own seductive charms to defeat O'Reilly's henchmen and save the world.