The Great Sioux Massacre is an entertaining pack of lies about Custer's Last Stand. General Custer (Philip Carey) is herein depicted as a bastion of tolerance, whose efforts to secure fair treatment for the Indians lead to several confrontations with corrupt government officials. Custer is forced to retire, but is soon approached by a machiavellian senator (Don Haggerty) who convinces the General that he is presidential material. The best way to attain the White House, Custer reasons, is to wrest control of the upcoming Little Big Horn campaign from the officer in charge (Frank Ferguson). This, alas, proves to be "Yellow Hair's" undoing. The Great Sioux Massacre costars Joseph Cotten and Darren McGavin as Custer's fellow officers Reno and Benton.