According to Universal-International publicity, The Lady Takes a Flyer is partially based on fact. The "lady" is Maggie Colby (Lana Turner) and the "flyer" is former Air Force colonel Mike Dandridge (Jeff Chandler). The two form a partnership when Mike decides to inaugurate an air-ferry service with Maggie as his chief pilot. Mike's wartime buddy Al Reynolds (Richard Denning) also signs on with the new service, though Al's hopes for a romance with Maggie are dashed when she marries Mike. Trouble arises when Maggie becomes pregnant and Mike insists that she give up her perilous lifestyle and become just another housewife. All conflicts are resolved during an exciting finale, wherein a fogbound Maggie is guided across the Atlantic via the radioed instructions of her loving husband.