The devastating reverberations of a profound tragedy echo through generations of a long-suffering French family in this emotional family drama from director Arnaud Desplechin. When Abel and his wife, Junon, started a family, it seemed like the seeds of true happiness had been planted. But while their daughter, Elizabeth, was healthy from the day she was born, things quickly turned dark when her brother Joseph was diagnosed with a rare and deadly genetic condition. Joseph's only hope for survival was a bone marrow transplant, but Abel, Junon, and Elizabeth were all incompatible. In one last, desperate chance to save their son's life, Abel and Junon conceived a third child. But not even little Henri could save his ailing brother's life. Joseph died at the age of seven, and neither his siblings nor his parents have ever found the strength to recover. Years later, family relations have deteriorated beyond the point of repair; the tensions between family matriarch Elizabeth and her cynical brother Henri finally culminating in a violent confrontation in which Elizabeth banishes her alcoholic brother and refuses him further contact with his troubled adolescent nephew, Paul.