When the Cat's Away is a gentle French comedy that explores the problems and anxieties of contemporary urbanites. When Chloe (Garance Clavel), a young Parisian, decides to take a long-overdue vacation, she has to find someone to look after Gris-Gris, her beloved cat. Everyone, including her gay male roommate, refuses to help her, but she finally makes an arrangement with the elderly Madame Renée (Renée Le Calm), who often watches over other peoples' cats and dogs. However, when Chloe comes back, Madame Renée tells her that unfortunately the cat has been lost, and the unlucky owner goes on a search for her dear animal friend. While looking for the cat, she meets many colorful characters who populate the neighborhood.