Pregnant 17-year-old Novalee Nation (Natalie Portman) runs away from her Tennessee home toward the bright lights of California, accompanied by her boyfriend, Willy Jack Pickens (Dylan Bruno). But Willy gets cold feet and abandons her at a Walmart in Sequoyah, OK. Novalee's life savings amount to $5.55, so she moves into the Walmart, sleeping there at night and venturing out during the day. With the help of the eccentric Sister Husband (Stockard Channing), and Lexie Coop (Ashley Judd), a nurses' aide, Novalee tries to get her life in order for the sake of her expected child, Americus Nation. Based on a novel by Billie Letts, Where the Heart Is also features Keith David, Joan Cusack, Richard Nance, and Heather Kafka.