Better known as It's Alive III, Island of the Alive details the further exploits of the murderous mutant infants introduced in director Larry Cohen's It's Alive! (1974). Said infants are shipped off to a desert island, where they are completely cut off from civilization. The government intends to eliminate the penned-up infants, but Michael Moriarty, the father of one of the babies, organizes a protest against this wholesale slaughter. It is clear to anyone who can read that director Cohen is drawing parallels between the quarantined children and society's treatment of AIDS victims. The strength of Cohen's direction and storytelling prowess is slightly weakened by some inadequate special effects in the closing scenes, wherein the babies reproduce and wreak havoc on the Mainland.

~ Hal Erickson, All Movie Guide