In post 9/11 Afghanistan, the American bombing has destroyed the most hated Taliban regime and the Taliban soldiers are trying to escape to Pakistan to avoid the wrath of the Afghans. Against this turbulent backdrop, Jai and Suhel--two Indian Television reporters--have entered Afghanistan and their aim is to somehow get a rare interview with a Talibani. Helping them in their pursuit of a Talibani is their Afghan guide, translator and driver, Khyber, in his Toyota Jeep called Kabul Express. The three of them are having their share of adventure as they go from being blindfolded and taken to secret hideouts in the mountains to interview Taliban prisoners to nearly getting trampled by horses while shooting a game of Buzkashi. They are saved from getting trampled by an American photojournalist, Jessica. Despite all their attempts, the Taliban remains elusive. But unknown to them, these hunters are being hunted down themselves. One cold winter morning in Kabul, they get kidnapped at gunpoint by a Taliban fugitive who wants to escape to the Pakistani border. The kidnapper, Imran, is a Pakistani soldier who was part of the Taliban. He knows that as journalists, Jai and Suhel's movements in the country will not be questioned and posing as their local guide, he can reach the safety of his country. Jai and Suhel's mission becomes a nightmare as they are taken hostage aboard the Kabul Express and made to drive across the most dangerous country in the world. Before she knows it, Jessica gets stuck in a bizarre situation and also gets taken hostage by Imran. Along the long treacherous route they get stopped by dangerous mercenary armed bandits, see an angry mob kill prisoners with their bare hands, and in a hilarious situation they even get chased by a suicidal donkey! Political and ideological boundaries not withstanding, all five of them are forced to act as a team in life threatening situations.