The sixth movie in the boy wizard franchise has earned $159.7 million (£106.5 million) in the U.S. since debuting worldwide on Wednesday (15Jul09).
The latest installment, starring Daniel Radcliffe as Potter, has also taken in $237 million (£158 million) overseas since its international opening, bringing its worldwide total in 54 countries to a staggering $396.7 million (£264.5 million).
The franchise's U.S. box office total soared above second place contender, animated comedy Ice Age: Dawn of the Dinosaurs, which took in $17.7 million (£11.8 million) in its third week.
Still in the third spot was action blockbuster Transformers: Revenge of the Fallen, with co-stars Shia LaBeouf and Megan Fox helping the franchise rake in another $13.8 million (£9.2 million). The film's four week total now boasts an impressive $363.9 million (£242.6 million).
Rounding out the top five are Sacha Baron Cohen's off-the-wall comedy Bruno - which was knocked from its first place ranking to number four - and The Hangover, which took in $8.4 million (£5.6 million) and $8.3 million (£5.5 million) respectively.