| Rank | Title | Gross Domestic Box Office | Adjusted Gross Domestic Box Office1 |
| 1 | Beverly Hills Cop (Paramount / 1984) | $234,760,478 | $433,887,669 |
| 2 | Home Alone (20th Century Fox / 1990) | $281,493,907 | $413,257,012 |
| 3 | Tootsie (Columbia Pictures / 1982) | $177,200,000 | $409,075,093 |
| 4 | Blazing Saddles (Warner Brothers / 1974) | $119,500,000 | $404,656,100 |
| 5 | National Lampoon's Animal House (Universal Pictures / 1978) | $141,600,000 | $383,297,700 |
| 6 | Mrs. Doubtfire (20th Century Fox / 1993) | $219,194,773 | $321,796,582 |
| 7 | Three Men and a Baby (Touchstone Pictures / 1987) | $167,780,960 | $310,095,167 |
| 8 | Austin Powers 2: The Spy Who Shagged Me (New Line Cinema / 1999) | $205,444,716 | $305,218,107 |
| 9 | Beverly Hills Cop 2 (Paramount Pictures / 1987) | $151,663,265 | $280,306,213 |
| 10 | Meet the Fockers (Universal Pictures / 2004) | $279,167,575 | $279,167,575 |
| 11 | Liar Liar (Universal Pictures / 1997) | $181,395,380 | $269,489,309 |
| 12 | There's Something About Mary (20th Century Fox / 1998) | $176,484,651 | $262,193,704 |
| 13 | My Big Fat Greek Wedding (IFC Films / 2002) | $241,437,427 | $258,059,625 |
| 14 | Porky's (20th Century Fox / 1982) | $111,289,673 | $256,917,795 |
| 15 | Home Alone 2 (20th Century Fox / 1992) | $172,676,450 | $253,503,724 |
| 16 | Look Who's Talking (Tristar Pictures / 1989) | $136,950,770 | $253,114,370 |
| 17 | Bruce Almighty (Universal Pictures / 2003) | $242,589,580 | $249,831,060 |
| 18 | Big Daddy (Columbia Pictures / 1999) | $163,479,795 | $242,873,093 |
| 19 | The Waterboy (Touchstone Pictures / 1998) | $161,487,252 | $239,912,879 |
| 20 | 9 to 5 (20th Century Fox / 1980) | $103,290,500 | $238,451,303 |
| 21 | Coming to America (Paramount Pictures / 1988) | $128,113,607 | $236,781,399 |
| 22 | Stir Crazy (Columbia Pictures / 1980) | $101,300,000 | $233,856,134 |
| 23 | Austin Powers in Goldmember (New Line Cinema / 2002) | $213,079,163 | $227,748,985 |
| 24 | Trading Places (Paramount Pictures / 1983) | $90,404,800 | $208,704,018 |
| 25 | Stripes (Columbia Pictures / 1981) | $85,297,000 | $196,912,405 |
| TOTALS | $4,287,081,722 | $7,169,107,020 |