The Wedding Crashers star, who married girlfriend Kyla Weber last weekend (02Jan10), is set to portray a man who discovers his best friend's wife is cheating in the upcoming movie.

It will be filmmaker Howard's first comedy in 11 years - he last made theatregoers giggle with Edtv in 1999 and has since become more well known for movies like A Beautiful Mind and Frost/Nixon, as well as bringing hit Dan Brown mystery/thriller books The Da Vinci Code and Angels & Demons to the big screen.

Vaughn will produce the project with Howard's Imagine Entertainment business partner Brian Grazer and shooting is set to begin in the spring (10), according to the Hollywood Reporter.