The Twilight hunk plays journalist Georges Duroy, who climbs the social ladder by sleeping with a series of prominent women.
The shoot will involve stripping off with numerous beautiful actresses including Christina Ricci and Kristin Scott-Thomas - and Pattinson admits he's nervous about getting naked with Thurman.
He says, "The sex scenes with Uma are kind of disturbing. Her character kind of uses sex as a weapon and my character thinks like an animal. There's quite a lot of sex scenes in this film, so I'm asking quite a lot of myself, and with lots of different people as well."