The two stars will be feted alongside model and TV personality Daisy Fuentes for their continuing support and dedication to children's causes around the world.
Saldana says, "I am so grateful for receiving this great honour and to be a part of St. Jude Children's Research Hospital. For me, the greatest reward is knowing that I am helping to bring awareness to the work of St. Jude and helping so many children in need around the world."
High School Musical stars Zac Efron and Vanessa Hudgens and Wilmer Valderrama will be among the presenters at the event, held in Los Angeles on 6 April (10).