The Hunger star appears alongside Antonio Banderas and Ewan McGregor in the film about a woman who is hunted by a group of assassins, but one of the choreographed action sequences went wrong - and it left Fassbender feeling ill after the violent shoot.
He tells Britain's Total Film magazine, "I had a lot of fun doing that (the stunts), we did all of that ourselves which actors get very proud about. I enjoy doing physical stuff.
"One thing they told me was, 'When the vase comes up, turn your head so it smashes the thing, don't look at the vase'. Of course in the first take I was like, 'Oh s**t!' Bang. Everything went bright for a few seconds and, of course, that's the take they used.
"We filmed the whole fight over two days and at the end of the second day I just remember I came back to the hotel and I puked up."