The star played a soldier who lost his lower limbs in hit movie Forrest Gump and he was moved when he heard of the plight of Lance Corporal Juan Dominguez.
As well as his legs, Dominguez also lost his right arm while serving in Sangin in 2010, and Sinise is hoping his charity event will raise enough to build a specially-equipped home for the solider in Temecula, California.
The actor will outline his plans for the concert, tentatively scheduled to be held on 1 March (12), to Temecula City Council on Tuesday (10Jan12).
In a statement obtained by the Los Angeles Times, Sinise says the event will "recognise the heroism, sacrifice and dedication Juan has displayed".
Last year (11), the actor set up the Gary Sinise Foundation to help aid troops and their families.