The star, who wrapped up her daily chat show last year (11), is eyeing a movie return in a biopic of Eugene Allen, who served eight U.S. presidents as a butler in the White House.
Producers are courting Winfrey to play Allen's wife, according to The Hollywood Reporter. Hugh Jackman, Mila Kunis and John Cusack are also attached to the project.
Winfrey won an Oscar nomination for her big screen debut in 1985's The Color Purple. Her last acting role was in 1998's Beloved, and she has since loaned her voice to animated projects The Princess and the Frog and Charlotte's Web.