The Green Card star is to play the lead role in the biopic of France's disgraced former IMF chief Dominique Strauss-Kahn, has been accused of sexually assaulting a chambermaid and was questioned by police over an alleged prostitution ring.
Depardieu knows exactly how to play the scandal-hit Frenchman, because Strauss-Kahn displays traits he abhors in his countrymen.
The actor tells Swiss chat show RTS, "He's not loveable. I think he's a bit like all the French, a bit arrogant. I don't much like the French in any case. And he's very French - arrogant, smug.
"He's playable. I will do it because I don't like him... We can all have filthy thoughts, and it's well known these guys with huge power can be like that. But I will not try to inhabit the role too deeply as I have never been moved by people who have no dignity."
The film will be directed by Abel Ferrara.