The Rosie Show premiered on OWN last year (Oct11) but it will end this month (Mar12).
The final episodes will tape next week (20Mar12) and the last show is set to air on 30 March (12).
The show failed to win over critics and struggled with ratings.
Announcing the news in a statement on Friday (16Mar12), Winfrey said, "I’m grateful to Rosie and the dedicated Rosie Show team for giving it their all."
O'Donnell added, "I loved working with Oprah... It was a great year for me. I wish the show was able to attract more viewers, but it did not... On we go!"