The Ocean's Twelve heartthrob's publicist Cindy Guagenti released a statement on behalf of the couple, after months of tabloid speculation their marriage was in trouble.
The statement says, "We would like to announce that after seven years together we have decided to formally separate.
"For those who follow these sorts of things, we would like to explain that our separation is not the result of any speculation reported by the tabloid media.
"We happily remain committed and caring friends with great love and admiration for one another."
The couple began dating in 1998 when they were set up on a blind date through their managers. They went on to wed in Malibu, California in July 2000.
Only days before Christmas Aniston was photographed without her wedding ring at Los Angeles' LAX airport. A week later the couple was photographed kissing and cuddling on the Caribbean island of Anguilla, where they were taking a New Year break with Aniston's Friends co-star Courteney Cox and her husband David Arquette.
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