The 40-year-old beauty was given the Editor's Special Award for her talent to combine motherhood, and a career while looking glamorous at the same time, as well as US TV Actress of the Year for her portrayal as single mother Susan Mayer in the hit show.
Accepting the award, Hatcher confessed, "I flew in today from California. I'm red-eyed, tired and drunk...I hope I inspire women to believe just how much can change in just one year."
Oscar-nominee Sophie Okonedo was another celebrity who had been enjoying the free champagne on offer at the star-studded bash in Berkeley Square Gardens.
As she accepted her trophy for Film Actress of the Year for Hotel Rwanda, she said, "I want to say something really witty, but I'm so drunk I don't know what to say! And I've got to present an award later in the evening, oh s**t."
Triumphant Usher, who picked up Man of the Year, laughed, "Man, I love these awards. You can say what you like."
Presenters at the ceremony, included The Backstreet Boys, Charlotte Church, Jack Osbourne and Geri Halliwell.
The full list of winners are:
Editor's Special Award: Teri Hatcher
Amor Amor Woman of the Year: Rachel Stevens
Man of the Year: Usher
UK TV Actress of the Year: Patsy Kensit (Emmerdale)
US TV Actress of the Year: Teri Hatcher (Desperate Housewives)
Theatre Actress of the Year: Kim Cattrall (Whose Life Is It Anyway)
TV Personality of the Year: Cat Deeley
Radio Personality of the Year: Jo Whiley
Newcomer of the Year: Mischa Barton (The O.C.)
Band of the Year: Destiny's Child
UK Solo Artist of the Year: Natasha Bedingfield
International Solo Artist of the Year: Gwen Stefani
Writer of the Year: J.K. Rowling
Entrepreneur of the Year: Elle Macpherson
Fashion Designer of the Year: Alice Temperley
Accessory Designer of the Year award: Tamara Mellon (Jimmy Choo)
Sportswoman of the Year: Kelly Holmes.
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