The cast of the Nickelodeon show will gather to shoot the finale this summer (12) before series star Miranda Cosgrove heads off to university in California.
Cosgrove and Jennette McCurdy, who play best friends and stars of a make-believe web show in the series, have been big hits among teenagers for the past five years.
The hit comedy, which also features Noah Munck, Nathan Kress and Jerry Trainor, debuted in 2007 and has featured guest spots from Cosgrove's School of Rock co-star Jack Black and U.S. First Lady Michelle Obama.
While Cosgrove concentrates on her education, her castmates have all landed new shows at Nickelodeon.
Announcing the news to end the series, creator Dan Schneider tells TV Guide magazine, "I hope iCarly's legacy will be that it's a truly funny TV show that made people of all ages laugh, smile, and feel good.
"To the iCarly fans, I'd say, 'Thank you' a million times, for the love, support and true passion they've shown for iCarly. It's the fans that made iCarly a huge hit, and invited us into their homes on a daily basis, to entertain them. How do you say thank you to millions and millions of people all around the world, for bringing you into their homes every single day? It's amazing. I'd love to take each and every iCarly fan out to dinner and give them a big ol' bear hug!"