The Frasier star bought the Holmby Hills in 2007 for just under $14 million (£8.75 million), according to Trulia.com.
The seven-bedroom spread boasts a pool, wine cellar and library.
Grammar and his fourth wife, Kayte Walsh, recently purchased a six-bedroom home in Beverly Hills.
The couple hopes to use the new mansion as a family base when they welcome twins this summer (12).
