The action blockbuster earned a total of four honours, including Best On-Screen Transformation (Elizabeth Banks) and Best Fight, but the coveted Best Movie title went to The Twilight Saga: Breaking Dawn - Part 1.
The vampire franchise also claimed victory for Best Kiss - Robert Pattinson and Kristen Stewart made it four years in a row, but the 22-year-old beauty was left to collect the award on her own as the British hunk was unable to attend.
The wizards weren't left out either - the stars of Harry Potter and the Deathly Hallows: Part 2 walked away with Best Cast.
Emma Stone's co-stars and friends Viola Davis, Mila Kunis, Jim Carrey and Steve Carell all hailed the actress with funny tributes as she was presented with the inaugural Trailblazer Award, and Johnny Depp was saluted by Aerosmith legends Steven Tyler and Joe Perry as they presented him with the Generation Award.
Depp also showed off his rock 'n' roll credentials by jamming with The Black Keys for a performance of Gold on the Ceiling before collecting his honour, and the actor admitted he was flattered to receive the accolade.
Accepting the Golden Popcorn prize, he joked, "This is quite an amazing honour, truly. It's like a 'Get out of the business' award, basically. It's like, 'Alright, you've done too much...' It's an honour to be presented by these two legends, Steven and Joe, and these up-and-coming legends, The Black Keys, so thank you very much."
Depp's collaboration with The Black Keys was the musical highlight of the night, but rapper Wiz Khalifa showed the crowd at Los Angeles' Gibson Amphitheatre a good time as he performed his new single, Work Hard, Play Hard, and fun. and Janelle Monae opened the show by performing their smash hit We Are Young.
Comedian Russell Brand provided the tongue-in-cheek laughs as the host of the ceremony, while guest presenters included Charlie Sheen, Charlize Theron, Mila Kunis, Jessica Biel and Mark Wahlberg.
The winners of the 2012 MTV Movie Awards are as follows:
Movie of the Year - The Twilight Saga: Breaking Dawn - Part 1
Best Male Performance - Josh Hutcherson (The Hunger Games)
Best Female Performance - Jennifer Lawrence (The Hunger Games)
Breakthrough Performance - Shailene Woodley (The Descendants)
Best Cast - Harry Potter and the Deathly Hallows: Part 2
Best On-Screen Transformation - Elizabeth Banks (The Hunger Games)
Best Fight - Jennifer Lawrence and Josh Hutcherson vs. Alexander Ludwig (The Hunger Games)
Best Hero - Daniel Radcliffe (Harry Potter and the Deathly Hallows: Part 2)
Best Kiss - Robert Pattinson and Kristen Stewart (The Twilight Saga: Breaking Dawn - Part 1)
Best On-Screen Dirtbag - Jennifer Aniston (Horrible Bosses)
Trailblazer Award - Emma Stone
Generation Award - Johnny Depp.