The Oscar winner picked up the rights for Cheryl Strayed's Wild four months before the novel was published, and now her foresight appears to have paid off - Winfrey has picked the tome for her revived book club.
Witherspoon and her Pacific Standard production partner Bruna Papandrea are planning to turn the story into a new movie, with The Kids Are All Right's Lisa Cholodenko as director.
Thrilled Papandrea says, "It was the first thing we picked up together," and Witherspoon tells The Hollywood Reporter, "Wild is a magical and evocative book about losing everything - family, money, your mother, your partner - and finding your true spirit alone in the woods."
Oprah's Book Club became a big part of the TV queen's former daytime talk show. It ended when Winfrey walked away from the show in 2010.