The couple has been dogged by split rumours since the beginning of the year (12), with gossips indicating the pair had grown apart and speculation continued to grow as both Depp and the singer played coy about the status of their relationship.
But now the parents of two have finally called it quits.
A statement released to Entertainment Tonight by the Pirates of the Caribbean star's publicist reads, "(They) have amicably separated. Please respect their privacy and, more importantly, the privacy of their children."
Depp and Paradis began dating in 1998 but never married. They have two children, Lily-Rose, 13, and Jack, 10.