The show, which is the world's second longest running daytime drama, picked up the event's biggest award, Best Drama, at the ceremony at the Beverly Hilton hotel in California.
General Hospital's haul also included Lead Actor in a Drama for Anthony Geary, while his co-stars Jonathan Jackson and Nancy Lee Grahn picked up the Supporting Actor and Actress prizes, respectively.
The directing team was also honoured.
Heather Tom was named Lead Actress in A Drama for The Bold and the Beautiful.
Meanwhile, rival soap Days of Our Lives also picked up two awards: Younger Actor in a Drama Series for Chandler Massey, as well as an Emmy for the writing team.
Retired entertainment legend Regis Philbin was honoured for his long tenure on TV with the Emmy for best talk-show host alongside his former co-anchor Kelly Ripa. Their popular programme, Live! With Regis And Kelly, also claimed best entertainment talk show, its first ever win in that category.
Other winners at the annual ceremony included Dr. Oz (informative talk show), Jeopardy! (game show), and Today (morning show).