The star won rave reviews for playing a Jewish Polish man trying to escape the Holocaust and received a Best Actor Academy Award for the role, but Brody admits the dark project left him with emotional issues.
He tells Britain's The Guardian: "(It was) all-consuming. For a good year after, I was probably seriously depressed.
"There were severe transitions that I put myself through physically and emotionally... I shot it when I was 27, and that was my real awakening and entrance into adulthood, that responsibility, and awareness of my own good fortune that I had taken for granted."