The former Frasier star's U.S. comedy Back to You failed to win over audiences in 2007 and it was axed after its first season, crushing Grammer's hopes of a major TV comeback.
Weeks later while paddleboarding in Hawaii in May, 2008 with his then-wife Camille, the actor suffered a major heart attack, which he largely attributes to stress, and he was hospitalised for several days before making a full recovery.
Now newly-remarried Grammer, who last month (Jul12) welcomed a baby girl with his wife Kayte Walsh, reveals he is grateful for the health scare because it inspired him to make several changes and take advantage of his new lease of life.
During an interview with U.S. TV series Oprah's Next Chapter, which aired in America on Sunday (26Aug12), he said, "It was a good thing in my life. It was a good event in my life.
"It was the physical manifestation of whatever lesson was being taught to me, which was you better fix it (your life) now. It took me another couple (of) years, but I did get it. And it was time I thought I had to change a few patterns."